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KMID : 1059519930370010131
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Journal of the Korean Chemical Society
1993 Volume.37 No. 1 p.131 ~ p.135
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died on the Synthesis of the 2-Desamino and 2-Desamino-2-Methyl Analogues of Aminopterin intermediate at Pteridine-C7 Side Chain
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Yu Euy-Kyung
Ryu Seoung-Ryuall
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Abstract
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A new series of 2-desamino, 2-desamino-2-methyl, and 2-amino analogues of aminopterin intermediates (7a), (7b), and (7c) were synthesized from 2-amino-3-cyano-6-chloromethylpyrazine. These derivatives were synthesized via two step sequence. Thus, cyclization of 2-amino-3-cyano-6-[(S-p-carbenzyloxyphenyl)thiomethyl]-pyrazine(14) with formamidine HCl, acetamidine HCl or guanidine HCl provided condensed compounds (15a), (15b) which upon base hydrolysis yielded the desired products (7a), (7b) and (7c).
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KEYWORD
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